Detroit Lions vs Buffalo Bills odds and betting data
This is the NFL event page for Detroit Lions vs Buffalo Bills. You can see and compare odds across different sportsbooks. The matchup is scheduled for Friday, September 18 at 12:15 AM UTC, and the odds tables below organize every available price by sportsbook, market, team, and outcome so you can quickly scan the best number before placing a bet.
Linewhale highlights the strongest current prices across 8 sportsbooks, including moneyline prices when available, spread points and prices, and over/under totals. Use this page to compare sportsbook odds, identify the best price for each side, review market differences, and open free line movement history for individual odds.
Free line movement for Detroit Lions vs Buffalo Bills
To see line movement for this event, use the odds table below and click a specific moneyline, spread, or total price. Linewhale will open a free line movement chart for the selected sportsbook and outcome for Detroit Lions vs Buffalo Bills, can review how that number has changed before you bet.
Moneyline· Pick the winner
| Side | CCaesars Sportsbook | DDraftKings | KKalshi | NNovig | PPolymarket | BBetRivers |
|---|---|---|---|---|---|---|
| Detroit Lions | ||||||
| Buffalo Bills | — |
Spread· Detroit Lions +3 / Buffalo Bills -3
| Side | CCaesars Sportsbook | DDraftKings | LLowVig.ag | BBetOnline.ag | BBetRivers |
|---|---|---|---|---|---|
Detroit Lions | +3 | +3 | +3 | +3 | +3 |
Buffalo Bills | -3 | -3 | -3 | -3 | -3 |
Spread· Detroit Lions +2.5 / Buffalo Bills -2.5
| Side | PPolymarket |
|---|---|
Detroit Lions | +2.5 |
Buffalo Bills | -2.5 |
Spread· Detroit Lions +3.5 / Buffalo Bills -3.5
| Side | NNovig |
|---|---|
Detroit Lions | — |
Buffalo Bills | -3.5 |
Total· O/U 52.5
| Side | CCaesars Sportsbook | DDraftKings | LLowVig.ag | PPolymarket | BBetOnline.ag | BBetRivers |
|---|---|---|---|---|---|---|
Over 52.5 | ||||||
Under 52.5 |
Detroit Lions vs Buffalo Bills betting odds overview
Compare NFL odds for Detroit Lions vs Buffalo Bills, scheduled for Friday, September 18 at 12:15 AM UTC. Linewhale tracks moneyline, spread, and total prices across major US sportsbooks so you can compare the best available number before placing a bet.
Best moneyline odds
Detroit Lions is listed at +138 on Kalshi, while Buffalo Bills is listed at -149 on Kalshi.
Best spread odds
The best listed spread prices are Detroit Lions +3 at -105 on LowVig.ag and Buffalo Bills -3 at -105 on LowVig.ag.
Best total odds
The best over price is -108 on Caesars Sportsbook; the best under price is -108 on LowVig.ag. The listed total is 52.5.
Odds can move quickly as sportsbooks adjust to injuries, lineup news, betting volume, and market-making books. Always confirm the final price at the sportsbook before submitting a wager.
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