NFL Betting Odds Preview: Week of September 28, 2026
Ten NFL games are on the board this week, and the betting odds span the full range from a near-coin-flip to one of the most lopsided spreads of the season. A Monday night opener in Chicago, a Thursday AFC North divisional rivalry, and eight Sunday games give you plenty of angles to work. Check the live NFL odds page to track line movement before you bet.
Monday Night Football
Philadelphia Eagles at Chicago Bears
Monday, 5:15 PM PDT
The Eagles open the week as clear road favorites. Philadelphia is priced at -192 (Novig) to -208 (BetMGM, Caesars), implying a 66 to 68 percent win probability. Chicago sits at +160 to +190 as the home underdog. The consensus spread is Eagles -3.5, though BetMGM has moved it to -4. If you want the Bears getting the hook, shop before that half-point fully migrates.
The total is 41.5 across nearly every book. BetOpenly (+104 Bears) and ProphetX (+101 Bears) offer the best underdog prices if you want to fade Philly laying field goal-plus on the road.
Thursday Night Football
Pittsburgh Steelers at Cleveland Browns
Thursday, 5:15 PM PDT
The AFC North rivalry gets its prime-time slot with the Steelers arriving as a moderate road favorite. Pittsburgh is priced between -132 (ProphetX) and -152 (BetRivers), clustering around -141 and implying roughly 58 percent. Cleveland is +115 to +127.
The spread is Steelers -2.5 at most books. LowVig.ag posts it at -105/-105, minimal hold on either side. The total is 38, one of the lower numbers on the week and consistent with how divisional games in tough conditions tend to play out. Browns +2.5 at -104 on Polymarket is the best available price if you think Cleveland keeps it close at home.
Sunday Slate
Indianapolis Colts at Washington Commanders
Sunday, 6:30 AM PDT
Indianapolis is a consistent road favorite at -156 (Polymarket) to -182 (BetRivers), with most books around -164, implying roughly 62 percent. Washington is a home dog in the +136 to +153 range.
The spread is Colts -3 at most books. FanDuel has moved it to -3.5 at -102, giving you the extra half-point at a cheaper price. If you're fading Indy on the number, BetMGM posts Washington +3 at +100, the cleanest price on that side. The total is 47.5 at most books, notably the highest of the early Sunday window.
New England Patriots at Buffalo Bills
Sunday, 10:00 AM PDT
The blowout candidate of the week. Buffalo is a massive home favorite at -270 (Polymarket) to -345 (BetMGM), implying a win probability north of 75 percent. New England is +232 (MyBookie.ag) to +275 (BetMGM).
The spread is Bills -7 at most books. LowVig.ag posts Bills -7 at +105 on the Buffalo side, a noticeably better number than the standard -105 elsewhere. If you want the Patriots covering, DraftKings and Caesars have them at +7 for -115, and Polymarket offers Patriots +6.5 at +104. The total is 48.5 across every book with almost no movement. At these odds levels, moneyline value on Buffalo is limited; the spread is where the more interesting line shopping lives.
Los Angeles Rams at Philadelphia Eagles
Sunday, 10:00 AM PDT
One week after the Eagles won in Chicago, they host the Rams as a home favorite. Philadelphia is priced at -130 (DraftKings, Novig) to -135 (BetMGM, FanDuel), implying 56 to 57 percent. The spread is Eagles -2.5 across the board. FanDuel posts it at -110/-110 and Kalshi has Eagles -2.5 at -104, the best available price on Philly. The total sits at 46.5 across the major books. This is one of the tighter markets on the Sunday slate with minimal spread between the best and worst prices. If you're weighing this game for a parlay, the Parlay Calculator can help you work out how combined implied probabilities affect your expected payout.
Jacksonville Jaguars at Cincinnati Bengals
Sunday, 10:00 AM PDT
Cincinnati is a modest home favorite, but the range of prices is wider than usual. The Bengals are priced from -120 (Novig) to -141 (BetMGM, BetOnline.ag), a gap that represents real edge if you shop carefully. The Jaguars are +107 (BetRivers) to +120 (LowVig.ag, BetOnline.ag).
The spread is Bengals -2.5 at most books. The total is the highest on the week at 51.5 at most books (51 at BetMGM and BetRivers), pointing to a game where both offenses are expected to produce. With a spread this tight and a total this elevated, either team can win outright. Jaguars +2.5 at even money on Novig and Polymarket is a notable price for a team getting 2.5 points.
Green Bay Packers at Tampa Bay Buccaneers
Sunday, 10:00 AM PDT
Green Bay is a road favorite at -159 (Novig, BetOpenly) to -175 (BetMGM, BetRivers, MyBookie.ag, DraftKings), placing them in the 62 to 64 percent implied probability range. Tampa Bay is +137 to +154.
The consensus spread is Packers -3.5 at most books, with BetRivers and BetUS at -3. The total is 39.5 at most books, the second-lowest on the Sunday slate, indicating a grind. On the Packers side, DraftKings has them -3.5 at -102, the best available price by a clear margin. If you're fading Green Bay, BetMGM posts Tampa +3.5 at -115.
Tennessee Titans at Baltimore Ravens
Sunday, 10:00 AM PDT
The most lopsided game on the slate. Baltimore is priced between -625 (Novig, LowVig.ag, BetOnline.ag) and -833 (ProphetX, MyBookie.ag), with an implied win probability of roughly 86 to 89 percent. Tennessee is +461 (LowVig.ag) to +600 (ProphetX).
The spread is Ravens -11.5 at most books. BetMGM posts it at -11, BetMGM is the book to use if you're on Baltimore, as that extra half-point matters significantly at this margin. Betting the Ravens moneyline means risking over six dollars to win one; the spread is the more sensible angle. The total is 43.5 across the board.
New York Jets at Chicago Bears
Sunday, 10:00 AM PDT
Chicago hosts for the second time in the week and this time as the favorite. The Bears are priced between -145 (Novig, BetOpenly) and -164 (FanDuel, MyBookie.ag), implying roughly 60 to 62 percent. The Jets are +124 (DraftKings) to +145 (BetOpenly).
The spread is Bears -3 at the majority of books. BetOpenly is a notable outlier, posting Bears -145 on the moneyline while listing the Bears-Jets spread at essentially a pick-em (-101/+101). That gap from the mainstream consensus is worth examining if you want the Jets with points. The total is split between 42.5 and 43 depending on the book, with the market balanced on both sides.
Arizona Cardinals at New York Giants
Sunday, 10:00 AM PDT
The pick-em of the week. BetMGM has it at Giants -108 vs. Cardinals -110. Bovada and DraftKings both post -110/-110. Novig and Polymarket actually flip the favorite, giving Arizona -112 with the Giants at +104. FanDuel has it Giants -110 vs. Cardinals -106.
When books cannot agree which team should be favored, the spread reflects that same uncertainty, ranging from Cardinals -1.5 (Polymarket, Kalshi, DraftKings) to a true pick-em at several others. Both teams sit just above 50 percent implied probability across the board. This is where line shopping pays off most. The Odds Converter can help you translate prices to implied probability quickly to find where the real edge is hiding.